idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Science Video Project
idw-Abo

idw-News App:

AppStore

Google Play Store



Instanz:
Teilen: 
13.04.2018 07:47

Non-coding RNA reveals its secrets

Dr. Arjan Vink Public Relations
Max-Planck-Institut für Hirnforschung

    Scientists from the Schuman Lab at the Max Planck Institute for Brain Research have investigated the variety of structures and functions in non-coding parts of messenger RNA (mRNA) from brain cells. These untranslated regions (UTRs) are essential for regulating the stability and localization of mRNAs, as well as its translation into proteins. The scientists will report their findings in the latest edition of Neuron.

    Our brain’s capacity to learn and to form memories relies on the ability to respond adaptively to environmental inputs. The integration of these inputs occurs at synapses, the connections between brain cells. Unlike other cell types in the body, neurons have an elaborate architecture, consisting of axons to transmit and dendrites to receive information. Like all cells, neurons use proteins to carry out their important cellular functions. Neurons supply their processes with proteins by moving mRNA molecules to the dendrites and axons where they can be locally translated.

    A mRNA molecule consists of a coding sequence in the middle, which serves as a template for new proteins, and two non-coding regions located on both ends: the 3’ region on the right and 5’ on the left hand side. These so-called untranslated regions (UTRs) control gene expression at the RNA level and are variable in length and composition. By acting as binding platforms, they can regulate stability, trafficking and translation, thus dictating the fate of an mRNA molecule within a cell.

    Researchers from the Schuman Lab now sequenced the mRNA present in different regions of rat hippocampal slices and took a closer look at the 3’ UTR region. Schuman: “When we examined mRNA in both neuronal cell bodies and in the neuropil, primarily consisting of axons and dendrites, we noticed a huge diversity in the 3’UTRs of neuronal mRNAs with many transcripts showing enrichment for a particular 3’UTR isoform in a cellular compartment. In addition, the isoforms enriched in the neuropil proved to be more stable than those located in the cell body.” The scientists were even able to follow the dynamics of these molecules during a period of enhanced neural activity and observed an alteration of 3’UTR isoforms present in each compartment. The Schuman team speculates that some of the changes in the dendritic compartment might be due to local remodeling of 3’UTRs.

    Publication: Tushev, G., Glock, C., Heumueller, M., Biever, A., Jovanovic, M. and Schuman, E.M. (2018). Alternative 3’UTRs modify the localization, regulatory potentia l, stability, and plasticity of mRNAs in neuronal compartments. Neuron, in press.


    Weitere Informationen:

    https://brain.mpg.de/news-events/news/news/archive/2018/april/article/non-coding...
    http://www.cell.com/neuron/fulltext/S0896-6273(18)30236-8


    Bilder

    Fluorescence in situ hybridization against the unique sequence of the long 3’ untranslated region of Camk2a in a hippocampal neuron.
    Fluorescence in situ hybridization against the unique sequence of the long 3’ untranslated region of ...
    Artwork by Maximilian Heumüller (Max Planck Institute for Brain Research)
    None


    Merkmale dieser Pressemitteilung:
    Journalisten, Studierende, Wissenschaftler
    Biologie, Chemie, Medizin
    überregional
    Forschungsergebnisse, Wissenschaftliche Publikationen
    Englisch


     

    Fluorescence in situ hybridization against the unique sequence of the long 3’ untranslated region of Camk2a in a hippocampal neuron.


    Zum Download

    x

    Hilfe

    Die Suche / Erweiterte Suche im idw-Archiv
    Verknüpfungen

    Sie können Suchbegriffe mit und, oder und / oder nicht verknüpfen, z. B. Philo nicht logie.

    Klammern

    Verknüpfungen können Sie mit Klammern voneinander trennen, z. B. (Philo nicht logie) oder (Psycho und logie).

    Wortgruppen

    Zusammenhängende Worte werden als Wortgruppe gesucht, wenn Sie sie in Anführungsstriche setzen, z. B. „Bundesrepublik Deutschland“.

    Auswahlkriterien

    Die Erweiterte Suche können Sie auch nutzen, ohne Suchbegriffe einzugeben. Sie orientiert sich dann an den Kriterien, die Sie ausgewählt haben (z. B. nach dem Land oder dem Sachgebiet).

    Haben Sie in einer Kategorie kein Kriterium ausgewählt, wird die gesamte Kategorie durchsucht (z.B. alle Sachgebiete oder alle Länder).