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23.09.2024 11:24

Health and Safety at Work: DFG Senate Commission Assesses the Risk of Chemical Compounds

Magdalena Schaeffer Presse- und Öffentlichkeitsarbeit
Deutsche Forschungsgemeinschaft (DFG)

    English version of current recommendations published / Contribution to EU debate: avoidance of animal experiments in chemical testing

    The Permanent Senate Commission for the Investigation of Health Hazards of Chemical Com-pounds in the Work Area of the DFG has now published the English version of its latest re-search-based recommendations on the risk assessment of substances used at the workplace. The recommendations have been submitted to the Federal Minister of Labour and Social Affairs in July. Compiled in 2024 for the 60th time, the annually prepared list of recommended limit val-ues serves as an essential basis for amendments to the Hazardous Substances Ordinance (GefStoffV) in Germany and is also used in other countries. The digital version of the recommen-dations is also available in English and Spanish in open access so that it may serve as a basis for occupational health and safety internationally.

    The recommendations put forward by the Senate Commission on the handling of hazardous substances are first assessed by the Federal Ministry of Labour’s Committee on Hazardous Sub-stances, and statutory regulations are subsequently drawn up on this basis as necessary. Re-garding the list of the last year, the Committee adopted all but one of the proposed limit values. “This reflects the outstanding scientific quality and longstanding experience of the Commission with regard to health protection in the occupational context,” said Commission chair Professor Dr. Andrea Hartwig. “The Senate Commission makes a significant contribution here in terms of the DFG’s mandate to provide scientific policy advice as stipulated in its statutes.”

    New health risk assessment for aluminium

    In terms of the current limit value recommendations, the Commission changed the risk assess-ment of 22 substances based on new scientific findings. It also added four new substances to its list of recommendations. One particularly noteworthy instance here is the intense debate sur-rounding the assessment of the metal aluminium and its inorganic compounds. Aluminium compounds are not only found at the workplace in the form of dust, for example during weld-ing, they are frequently used in other contexts as well, such as in the treatment of water.

    The Commission derived a total of four limit values for different groups of aluminium com-pounds. These figures indicate the maximum workplace concentrations (MAK values), i.e. the quantities of a substance that are not expected to cause any long-term harm at the workplace as a gas, vapour or aerosol in the air. Following a critical evaluation of the literature – in partic-ular considering studies that postulate a causal link between aluminium and breast cancer – the Senate Commission stated that aluminium was not classified as carcinogenic providing the MAK value was adhered to.

    The Commission’s current recommendations specifically contain eight new MAK values. In ad-dition, the recommendations indicate the concentration of a substance in the body to which a person can be exposed during a working lifetime without experiencing adverse health effects: this year, the list contains three changes to such biological tolerance values. The recommenda-tions also include information on whether a substance can cause cancer, damage germ cells, harm a developing foetus during pregnancy, sensitise the skin or respiratory tract, or are ab-sorbed in toxic quantities through the skin.

    Detailed scientific documentations are available for each of the substances reviewed. In order to ensure that the recommendations are up to date with the latest scientific findings, the proposed amendments and new additions remain open for discussion until 31 December 2024. New data or scientific comments can be submitted to the Commission up until that date.

    All substance documentations and methodological descriptions prepared by the Senate Commis-sion along with the annually published recommendations (List of MAK and BAT Values) are to be found in the MAK Collection. In addition to the latest results of the Commission’s scientific work, all other publications are likewise available in open access, ensuring that the findings are presented in a form that enables comprehensive scientific reuse.

    Active engagement in the area of European chemicals policy

    In addition to providing scientific policy advice on national occupational health and safety legis-lation, the Commission is also involved in advising on European chemicals policy. Together with the DFG’s Permanent Senate Commission on Animal Research, the Senate Commission con-tributed a research perspective to the current debate on an EU roadmap for abandoning ani-mal-based methods in chemicals testing, which is due to be published in 2025.

    On the one hand, the two Commissions highlighted the potential offered by various New Ap-proach Methods (NAMs). According to the researchers, these have the capacity to reduce the number of animal experiments and to use existing findings more systematically to be able to arrive at a quantitative risk assessment as a requirement for deriving limit values. The new methods include conducting studies on cell cultures or organoids – small pieces of tissue pro-duced in the laboratory that are very similar to many organs, including the liver, the kidney and the brain – and also methods using data integration and simulation.

    On the other hand, the Senate Commissions pointed out that extensive research will be still needed to assess the possibilities and limitations of the new methodologies before potentially displacing animal experiments entirely without accepting higher risks at the workplace and be-yond.

    Further information

    For the current list of recommendations (“2024 List of MAK and BAT Values”), open access MAK Collection publi-cations and further information on the work of the Senate Commission, see:
    www.dfg.de/mak/en

    Media contact:
    DFG Press and Public Relations, Tel. +49 228 885-2109, presse@dfg.de

    Editorial offices can request a free review copy.

    Secretariat of the DFG Permanent Senate Commission for the Investigation of Health Hazards of Chemical Com-pounds in the Work Area:
    Dr. Gunnar Jahnke and Dr. Gerlinde Schriever-Schwemmer, Tel. +49 721 608-47400, mak_sekr@iab.kit.edu

    Programme contact at the DFG Head Office:
    Dr. Katja Hartig, Life Sciences, Tel. +49 228 885-2359, arbeitsstoffkommission@dfg.de

    A German version of this press release was published on 01 July 2024 on the occasion of the submission of the latest recommendations to the Federal Minister of Labour and Social Affairs:
    https://www.dfg.de/de/service/presse/pressemitteilungen/2024/pressemitteilung-nr...


    Weitere Informationen:

    http://www.dfg.de/mak/en


    Bilder

    Merkmale dieser Pressemitteilung:
    Journalisten, Wissenschaftler
    Chemie, Ernährung / Gesundheit / Pflege, Medizin
    überregional
    Wissenschaftspolitik
    Englisch


     

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