idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Science Video Project
idw-Abo

idw-News App:

AppStore

Google Play Store



Instance:
Share on: 
07/04/2018 09:00

Jacobs University researchers explain how herpesviruses escape from the immune system

Thomas Joppig Corporate Communications & Public Relations
Jacobs University Bremen gGmbH

    Herpesviruses are the cause of many diseases, such as shingles or mononucleosis ('kissing disease') that compromise our quality of life. While the human immune system can usually prevent the spread of herpesviruses, it cannot entirely eliminate them from our bodies. This is because these viruses contain a vast arsenal of factors that thereby conceal the virus from the immune system. These are the so-called immuno-evasins. The research group of Sebastian Springer, Professor of Biochemistry and Cell Biology at Jacobs University Bremen, have now explained the function of one such immuno-evasin.

    When herpesviruses infect a cell and multiply, they can be detected by the T cells of the immune system because the infected cell will show certain proteins on its surface, the so-called MHC-I proteins. These proteins act as a warning signal: they bind other proteins on the surface of the T cell and activate it to destroy the virus-infected cell. The herpesvirus MCMV blocks this warning signal: it contains a factor, known as gp40, that prevents the transport of the MHC-I proteins to the cell surface. The virus evades the immune response, and so gp40 belongs to the class of the immuno-evasins.

    The Springer group, supported by DFG and the Tönjes Vagt Foundation of Bremen, have now gathered decisive insights into how the gp40 immunoevasin achieves its function. Springer describes the processes with a simple analogy: "Imagine that gp40 has two hands. With one hand, It holds on to a fixed point within the cell, and with the other hand, it grabs the MHC-I protein. Of course now, the MHC-I protein can no longer make its way to the cell surface." Springer’s PhD student, Venkat Raman Ramnarayan, has managed to identify this fixed point in the cell interior, and it turned out to be a cellular protein called TMED10, with which the Springer Lab was already familiar. "We were very well equipped to investigate the interaction between gp40 and TMED10", says Springer. "And now, we also know how the MCMV virus can escape from the immune response."

    The results, which have already been published in the prestigious journal "Cell Reports", are not directly useful for patients, yet they do lay the foundation for future therapies which can strengthen and support the immune response against viral infections.

    Source: 

    Cell Reports 23 (2018), 3068-3077
    https://www.cell.com/cell-reports/pdf/S2211-1247(18)30750-2.pdf
    Questions will be answered by: 

    Prof. Dr. Sebastian Springer | Professor of Biochemistry and Cell Biology
    s.springer@jacobs-university.de | Tel.: +49 421 200-3243

    http://springergroup.user.jacobs-university.de/news/

    About Jacobs University Bremen:
    Studying in an international community. Obtaining a qualification to work on responsible tasks in a digitized and globalized society. Learning, researching and teaching across academic disciplines and countries. Strengthening people and markets with innovative solutions and advanced training programs. This is what Jacobs University Bremen stands for. Established as a private, English-medium campus university in Germany, it is continuously achieving top results in national and international university rankings. Its almost 1,400 students come from more than 100 countries with around 80% having relocated to Germany for their studies. Jacobs University’s research projects are funded by the German Research Foundation or the European Research Council as well as by globally leading companies.
    For more information: https://www.jacobs-university.de
    https://www.facebook.com/jacobs.university
    https://www.youtube.com/user/JacobsUni
    https://twitter.com/jacobs_bremen
    https://www.instagram.com/jacobsuniversity/
    https://www.weibo.com/jacobsuniversity

    Thomas Joppig | Corporate Communications & Public Relations
    Jacobs University Bremen gGmbH
    Campus Ring 1 | 28759 Bremen | Germany
    Phone: +49 421 200 4504 | Fax +49 421 200 494504
    t.joppig@jacobs-university.de
    https://www.jacobs-university.de

    Commercial registry: Amtsgericht Bremen, HRB 18117
    President/ Managing Director: Prof. Dr. Michael Hülsmann (Geschäftsführer)
    Chair Board of Governors: Prof. E. Jürgen Zöllner (Aufsichtsratsvorsitzender)


    Images

    The research group of Professor Sebastian Springer (sitting in the first row) at Jacobs University Bremen.
    The research group of Professor Sebastian Springer (sitting in the first row) at Jacobs University ...
    Photo: Jacobs University
    None

    PhD student Venkat Raman Ramnarayan
    PhD student Venkat Raman Ramnarayan
    Photo: Jacobs University
    None


    Criteria of this press release:
    Journalists
    Biology, Chemistry, Medicine, Nutrition / healthcare / nursing
    transregional, national
    Research results, Scientific Publications
    English


     

    The research group of Professor Sebastian Springer (sitting in the first row) at Jacobs University Bremen.


    For download

    x

    PhD student Venkat Raman Ramnarayan


    For download

    x

    Help

    Search / advanced search of the idw archives
    Combination of search terms

    You can combine search terms with and, or and/or not, e.g. Philo not logy.

    Brackets

    You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).

    Phrases

    Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.

    Selection criteria

    You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).

    If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).