idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Grafik: idw-Logo

idw - Informationsdienst


07.09.2012 17:00

US Researchers Discover Surprising New Roles for a Key Regulatory Enzyme of Blood Pressure

Barbara Bachtler Pressestelle
Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch

    Many patients with hypertension are treated with ACE inhibitors. These drugs block the angiotensin converting enzyme (ACE) that regulates the salt and water balance of the body and raises blood pressure. Recent studies by Professor Ken Bernstein (Cedars-Sinai Medical Center, Los Angeles, USA) have, however, significantly broadened the enzyme’s known task spectrum: The enzyme also plays a key role in blood formation, renal development and male fertility. In addition, ACE has a hitherto unexpected influence on the immune response, he reported at the 1st ECRC Franz Volhard Symposium on September 7, 2012 at the Max Delbrück Center (MDC) in Berlin-Buch.

    Professor Ken Bernstein reported that in mice an excess of ACE led to a much stronger immune response than usual. In animal experiments, not only could bacterial infections be combated more effectively, but also the growth of aggressive skin cancer (melanoma) in mice could be contained by a stronger response of the immune system. In contrast, if the mice lacked ACE, the immune cells worked less effectively.

    In addition, ACE apparently has an influence on blood formation. It has been known for many years that, in humans, ACE inhibitors induce a small reduction of red blood cell levels. To elucidate the exact roles of ACE, the Bernstein’s research team deactivated the genes in mice that normally provide the blueprint for the enzyme. As a consequence, these so-called “knock out” mice could no longer produce the enzyme. The examination of these mice revealed that they in fact had significantly fewer red blood cells. Also, the white blood cells in these animals were less functional. According to the researchers’ studies, ACE evidently plays a role in the development of the different blood cells.

    Bernstein's team also showed that ACE apparently plays an important role in the development of the kidneys. In mice that could not produce the enzyme, the small arteries and the tissue of the kidneys revealed pathological changes, and the urine flow was impaired.

    According to these findings, male fertility is also associated with ACE. Male mice lacking ACE continued to produce sperm, but they were no longer able to reproduce. However, if in the mice not the enzyme itself, but rather a product of ACE – namely the hormone angiotensin II – was suppressed, they could continue to reproduce. Until now it was thought that ACE mainly exerts its effect through the production of angiotensin II. These results show, however, that ACE is enzymatically active and produces other active products apart from angiotensin II, for example in the testes.

    Barbara Bachtler
    Press Department
    Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
    in the Helmholtz Association
    Robert-Rössle-Straße 10
    13125 Berlin, Germany
    Phone: +49 (0) 30 94 06 - 38 96
    Fax: +49 (0) 30 94 06 - 38 33

    Merkmale dieser Pressemitteilung:
    Journalisten, Wissenschaftler
    Biologie, Medizin
    Wissenschaftliche Tagungen


    Die Suche / Erweiterte Suche im idw-Archiv

    Sie können Suchbegriffe mit und, oder und / oder nicht verknüpfen, z. B. Philo nicht logie.


    Verknüpfungen können Sie mit Klammern voneinander trennen, z. B. (Philo nicht logie) oder (Psycho und logie).


    Zusammenhängende Worte werden als Wortgruppe gesucht, wenn Sie sie in Anführungsstriche setzen, z. B. „Bundesrepublik Deutschland“.


    Die Erweiterte Suche können Sie auch nutzen, ohne Suchbegriffe einzugeben. Sie orientiert sich dann an den Kriterien, die Sie ausgewählt haben (z. B. nach dem Land oder dem Sachgebiet).

    Haben Sie in einer Kategorie kein Kriterium ausgewählt, wird die gesamte Kategorie durchsucht (z.B. alle Sachgebiete oder alle Länder).