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Image for: Interplay of genes: The understudied transcription factor RFX7 has a central role in growth and cancer


Stress activates p53. This leads to the activation of RFX7, which, like p53, is a transcription factor and tumor suppressor. RFX7 inhibits the kinases AKT and mTORC1, important regulators of cell growth, which may enable RFX7 to suppress cancer.
Stress activates p53. This leads to the activation of RFX7, which, like p53, is a transcription factor and tumor suppressor. RFX7 inhibits the kinases AKT and mTORC1, important regulators of cell growth, which may enable RFX7 to suppress cancer.

(Source: FLI / Kerstin Wagner; created with BioRender.com)

(275 KB, 2418 x 1224 pixels)

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