Attempts at finding neuroprotective agents for stroke have failed to date. We believe these failures are directly related to the use of models based on young rodents for a disease that principally effects the elderly. We have been studying an aged model of embolic ischemia to overcome these limitations. We examined the effects of age on stroke progression and outcome in order to explore the association between blood-brain barrier (BBB) disruption, neuronal damage, and functional recovery. Our data show that aged rodents "experience" a very different stroke from that seen in the common young animal model of ischemia. Furthermore, fragility of the blood brain barrier may explain this profound difference.
Charles Lee Rosen ist Direktor der Abteilung für Schädelbasis- und Neurochirurgie an der West Virginia University in Morgantown, USA. Dort zeichnet er verantwortlich für Forschungen zum Verlauf von Schlaganfällen unter Berücksichtigung des Alters.
Moderation: Professor Dr. Aurel Popa-Wagner
Information on participating / attending:
Der Eintritt ist frei.
Date:
05/07/2008 18:00 - 05/07/2008
Event venue:
Alfried Krupp Wissenschaftskolleg Greifswald
Martin-Luther-Straße 14
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
regional
Subject areas:
Biology, Information technology, Medicine, Nutrition / healthcare / nursing
Types of events:
Entry:
05/02/2008
Sender/author:
Stefan Klatt
Department:
Alfried Krupp Wissenschaftskolleg Greifswald
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event23468
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