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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. The development of specific antiviral therapies and a vaccine has proven difficult due to the lack of an adequate in vivo model. We therefore aim to create a small primate model for HCV pathogenesis by systematically identifying and overcoming the blocks to infection in rhesus macaques. Macaque cell lines and primary macaque hepatocytes neither support viral entry nor replication. To pinpoint the block in viral entry, we cloned the HCV entry factors and demonstrated that the tetraspanin CD81 supports viral entry less efficiently than its human ortholog. We adapted the viral glycoproteins for efficient use of macaque CD81 by in vitro selection and achieved transient viral replication in macaque cells. These results indicate that HCV can adapt to a macaque host for hepatitis C and for HCV/HIV co-infections.
Who ist Gisa Gerold?
• Postdoctoral fellow at the Laboratory of Virology and Infectious Disease / Center for the Study of Hepatitis C at the Rockefeller University in New York
• Recipient of Postdoctoral Fellowships from the German Academy of Science Leopoldina and the Human Frontier Science Program
Before:
• Previously, engaged in the investigation of human innate immune responses to bacterial pathogens at the Max Planck Institute for Infection Biology in Berlin
Information on participating / attending:
Date:
04/13/2011 12:30 - 04/13/2011 14:00
Event venue:
TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung
TWINCORE Lecture Hall
Feodor-Lynen-Str. 7
30625 Hannover
Niedersachsen
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
regional
Subject areas:
Biology, Medicine, Nutrition / healthcare / nursing
Types of events:
Presentation / colloquium / lecture, Seminar / workshop / discussion
Entry:
01/25/2011
Sender/author:
Dr. Jo Schilling
Department:
Presse- und Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event33912
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