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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Adaptive immunity plays an important role protecting vertebrates against a broad range of pathogens and cancer. The major histocompatibility complex (MHC) class I-dependent pathway of antigen presentation represents a sophisticated strategy to recognize and eliminate infected or malignantly transformed cells, taking advantage of the constant proteasomal turnover of the cellular proteome. The transporter associated with antigen processing (TAP) is a crucial component of this pathway, catalyzing the peptide translocation and loading of MHC I complexes in the ER-lumen. The peptide-loading complex (PLC) consists of the antigen ABC transport complex TAP1/2, MHC I heavy chain, 2-mircoblobulin, calreticulin, the disulfide isomerase ERp57, and the adapter protein tapasin. The molecular mechanism of the antigen translocation machinery, the structural organization of the macromolecular peptide-loading complex, and various modes of regulation by newly identified viral factor will be discussed.
Who is Robert Tampé?
• Full Professor & Director, Institute of Biochemistry, Biocenter, Goethe- University, Frankfurt.
• Guest Professor, University of California San Francisco (UCSF).
• Visiting Professor, iCeMS, Kyoto University, Japan.
• Coordinator, Research Center (SFB 807) Transport and Communication across Cell Membranes.
Information on participating / attending:
Date:
05/04/2011 15:00 - 05/04/2011 17:00
Event venue:
TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung
TWINCORE Lecture Hall
Feodor-Lynen-Str. 7
30625 Hannover
Niedersachsen
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
regional
Subject areas:
Biology, Chemistry, Medicine, Nutrition / healthcare / nursing
Types of events:
Presentation / colloquium / lecture, Seminar / workshop / discussion
Entry:
04/15/2011
Sender/author:
Dr. Jo Schilling
Department:
Presse- und Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event35004
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