idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Prof. Dr. Jan-Erling Bäckvall
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University:
The combination of a catalytic racemization procedure and an enzymatic resolution can lead to a
dynamic kinetic resolution (DKR) if the enzyme and racemization catalysts are compatible with
one another. The advantage with this approach is that all of the racemic substrate can be
transformed into enantiomerically pure product in up to 100% yield. Efficient procedures for
DKR of alcohols and amines by combining an enzyme with a metal racemization catalyst have
been used in enantioselective organic synthesis of biologically active compounds.
The mechanism of the racemization of alcohols catalyzed by (5-pentaphenylcyclopentadienyl)-
RuCl(CO)2 was recently studied. The racemization involves an alkoxide complex that undergoes
a b-elimination followed by readdition of the hydride.
Model studies on Lipases A and B from Candida Antarctica as well as a successful directed
evolution of the Lipase A were carried out.
Einladender: Prof. Dr. Uwe Bornscheuer
gez. Prof. Dr. J. Heinicke
Vorsitzender des Ortsverbandes der
GDCh
Information on participating / attending:
Date:
05/19/2011 17:00 - 05/19/2011
Event venue:
Großer Hörsaal des Instituts für Biochemie
Felix-Hausdorff-Str. 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Business and commerce, Scientists and scholars
Email address:
Relevance:
transregional, national
Subject areas:
Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
05/06/2011
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event35297
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