During their lifetime, all types of cellular life face the constant threat of parasite genome invaders. In Bacteria and Archaea, CRISPR/Cas has recently emerged as an RNA-mediated adaptive immune mechanism against exogenous genetic elements. The system also known as the prokaryotic RNA interference (RNAi) pathway is composed of CRISPR-associated (Cas) proteins and short RNA molecules (CRISPR RNAs:crRNAs). The crRNAs consist of unique repeat/spacer sequences and commonly guide the Cas protein(s) to cognate invading nucleic acids for their destruction. A key event in CRISPR activation is the maturation of crRNAs.
We recently focused on one particular CRISPR/Cas system in the severe human pathogen Streptococcus pyogenes and discovered a unique crRNA biogenesis pathway together with a novel biological function of the immune pathway. A short overview of other lab projects regarding regulatory processes in Gram-positive bacterial pathogenicity will also be presented.
Who is Emmanuelle Charpentier?
•Faculty Positions: Assoc. Prof. MIMS, UCMR, Dep. of Molecular Biology, Umeå University, Sweden; Assoc. Prof. Max F. Perutz Laboratories, Univ. of Vienna, Austria; Assist. Prof. Dep. of Microbiology and Immunobiology, Univ. of Vienna, Austria; Guest Prof., Inst. of Microbiology and Genetics, Univ. of Vienna, Austria.
•Docent Degrees: Privat-Dozent, Habilitation in Microbiology, University of Vienna, Austria (2006); Docent, Faculty of Medicine, Umeå University, Sweden (2012).
Information on participating / attending:
Date:
02/16/2012 15:00 - 02/16/2012 17:00
Event venue:
TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung
TWINCORE Lecture Hall
Feodor-Lynen-Str. 7
30625 Hannover
Niedersachsen
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
regional
Subject areas:
Biology, Chemistry, Medicine
Types of events:
Presentation / colloquium / lecture, Seminar / workshop / discussion
Entry:
01/18/2012
Sender/author:
Dr. Jo Schilling
Department:
Presse- und Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event38186
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