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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract: Entomopathogenic bacteria of the genera Photorhabdus and Xenorhabdus live in symbiosis with nematodes of the genera Heterorhabditis and Steinernema, respectively, and have been shown to be prolific producers of natural products.1 A detailed analysis of 300 different strains of these bacteria grown without nematodes led to the identification of several natural products that are novel and often conserved in specific phylogenetic clades of these bacteria thus indicating also specific conserved functions of these compounds. Current efforts in our group deal with the activation and optimization of secondary metabolite production via the manipulation of specific or global regulators, the exchange of natural promoters against strong or inducible ones, and the production of compounds, which are specifically produced exclusively in insects. Among the novel compound classes identified during our work are several new nonribosomally made peptides or peptide derivatives, widespread but overlooked dialkylresorcinols and cyclohexanediones, pyrones acting as a novel bacterial signalling system, and structurally unique polyamine natural products named fabclavines. The major goal of our work is to elucidate the natural function of these compounds as well as the regulatory mechanisms that enable their production.
[1] Bode, H. B., Curr. Opin. Chem. Biol. 2009, 13, 224.
Information on participating / attending:
Einladender: Prof. Dr. Michael Lalk
PD Dr. Heike Kahlert, Vorsitzende des Ortsverbandes der GDCh
Date:
01/27/2014 16:15 - 01/27/2014 17:15
Event venue:
Institut für Biochemie, Großer Hörsaal
Felix-Hausdorff-Straße 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Relevance:
regional
Subject areas:
Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
12/13/2013
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
no
Language of the text:
German
URL of this event: http://idw-online.de/en/event45796
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