idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract: Our latest work on pyranopterin molybdenum enzymes focuses on understanding electronic structure contributions to substrate oxidation and reduction, as well as how the Mo center is coupled into long-range superexchange pathways for electron transfer regeneration of the active site. First, we present our studies on the unique pyranopterin dithiolene ligand, which is comprised of a dithiolene and a heterocyclic pterin ring system that are connected by a pyran ring. Roles suggested for the pyranopterin dithiolene in catalysis include acting as an electronic conduit to couple the Mo ion with other electron transfer centers in the protein, and modulating the Mo reduction potential. We will show our latest spectroscopic and bonding studies that detail how the pyranopterin is involved in electron transfer. This includes a remarkable study, which shows that the redox state of the pyranopterin affects its ability to display either “wire-like” or “diode” behavior, supporting a complex and flexible electronic structure of the pyranopterin dithiolene that underscores its critical role in enzyme function. Second, we will present our most recent work on the electronic structure and mechanism of xanthine oxidase (XO) and the related Mo-Cu carbon monoxide dehydrogenase (CODH). Spectroscopic studies, coupled with a detailed orbital analysis, provide new insight into the mechanism of these enzymes. Importantly, these studies reveal electronic structure contributions to reactivity that are remarkably similar for both CODH and XO in spite of their different function.
Information on participating / attending:
Die Veranstaltung findet am 16. Oktober um 17:15 Uhr im Großen Hörsaal des Instituts für Biochemie, Felix-Hausdorff-Straße 4, 17489 Greifswald, statt. Gäste sind herzlich willkommen.
Einladende: Prof. Dr. Carola Schulzke
PD Dr. Heike Kahlert, Vorsitzende des Ortsverbandes der GDCh
hkahlert@uni-greifswald.de
Date:
10/16/2014 17:15 - 10/16/2014 18:15
Event venue:
Institut für Biochemie, Großer Hörsaal
Felix-Hausdorff-Straße 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Relevance:
transregional, national
Subject areas:
Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
09/29/2014
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
no
Language of the text:
German
URL of this event: http://idw-online.de/en/event48493
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