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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed
light on the contribution of individual ISG effectors, but most have examined those acting on early, intracellular
stages of the viral life cycle. We applied an image-based screen to identify ISGs inhibiting late stages of
influenza A virus (IAV) infection. We unraveled a directly antiviral function for the gene SERPINE1, encoding plasminogen activator inhibitor 1 (PAI-1). PAI-1 inhibits IAV glycoprotein cleavage, thereby reducing infectivity of progeny viruses. This was relevant for IAV restriction in vivo. Further, partial PAI-1 deficiency, attributable to a polymorphism in human SERPINE1, conferred increased susceptibility to IAV in vitro. Our findings reveal that manipulating the extracellular environment to inhibit the last step in a virus life cycle is an important mechanism of the antiviral response.
Information on participating / attending:
Date:
03/27/2015 13:00 - 03/27/2015
Event venue:
TWINCORE,
Zentrum für Experimentelle und Klinische Infektionsforschung GmbH
Feodor-Lynen-Str. 7
TWINCORE Lecture Hall
30625 Hannover
Niedersachsen
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
transregional, national
Subject areas:
Biology, Chemistry, Medicine, Nutrition / healthcare / nursing
Types of events:
Seminar / workshop / discussion
Entry:
02/26/2015
Sender/author:
Dr. Jo Schilling
Department:
Presse- und Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event50100
Poster TWINCORE-Seminar M. Dittmann You can combine search terms with and, or and/or not, e.g. Philo not logy.
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