idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract
Cancer is a genetic disorder driven by oncogenic mutations, and DNA damage caused by reactive oxygen species (ROS) is part of the underlying mechanism. Since ROS levels are kept in check by antioxidants, a widely accepted dogma is that dietary supplements containing high concentrations of antioxidants protect against cancer. However, clinical trials have not supported this view, and some even showed that antioxidants
increase cancer risk.
Recent data from our lab has begun to shed light on this paradox. We found that antioxidants accelerated the progression of lung tumors in mice and the growth of human lung cancer cell lines, and propose a simple mechanism. By reducing levels of ROS and DNA damage, antioxidants deactivate the tumor suppressor p53 and increase tumor cell proliferation. I will discuss these findings at the seminar and present recent data on the impact of antioxidants on other cancer types. I will also discuss the potential of pro-oxidant preventive cancer therapies.
Further reading: Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P*, Bergo MO* (2014) Antioxidants accelerate lung cancer progression in mice. Science Translational Medicine.6 (221), pp.221ra215, *contributed equally.
All interested are cordially invited!
Information on participating / attending:
Organisation
Anett Stolte, Koordinatorin RTG 1947
Institut für Physik, Felix-Hausdorff-Straße 6, 17489 Greifswald
Telefon 03834 86-4436, anett.stolte1@uni-greifswald.de
Date:
11/06/2015 14:00 - 11/06/2015 15:30
Event venue:
Institut für Biochemie, SR D213
Felix-Hausdorff-Straße 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Relevance:
international
Subject areas:
Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
10/06/2015
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
no
Language of the text:
German
URL of this event: http://idw-online.de/en/event52142
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