idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract
During the last decade the effect of neoplastic transformation on the metabolism and the knowledge about the molecular mechanisms of the cellular adaption to hypoxia has increased, but there exists little information about the overlap and differences in gene/protein expression of both processes as well as the consequences on the tumor microenvironment, immune modulatory molecules and immune responses. Therefore the aim of this study was to dissect oncogene- and tumor suppressor-mediated and hypoxia-regulated alterations on (i) the metabolism of tumor cells, (ii) the tumor microenvironment and (iii) immune responses. In addition, the observed alterations were modulated/reversed by drugs and small molecules. Using different experimental approaches including ome-based strategies the effect of oncogene-/tumor suppressor gene- and hypoxia-regulated altered gene/protein expression pattern on the cellular metabolism, immune responses and their modulation by diverse substances was analysed by determination of glucose uptake, lactate secretion, extracellular pH, lactate dehydrogenase activity, amino acid content, ATP levels and T cell activity.
Further reading
Leisz S, Schulz K, Erb S, Oefner P, Dettmer K, Mougiakakos D, Wang E, Marincola FM, Stehle F, Seliger B. (2015) Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism. Oncotarget. 2015 May 10; 6(13):11395-406.
All interested are cordially invited!
Information on participating / attending:
Kontakt
Anett Stolte, RTG 1947 Coordinator
Institute of Physics, Felix-Hausdorff-Str. 6, 17489 Greifswald
Tel. 03834 86-4436, anett.stolte1@uni-greifswald.de
Date:
01/15/2016 14:15 - 01/15/2016 15:15
Event venue:
SR D 213, Biochemie
Felix-Hausdorff-Straße 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Relevance:
regional
Subject areas:
Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
01/06/2016
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
no
Language of the text:
German
URL of this event: http://idw-online.de/en/event52954
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