idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Grafik: idw-Logo

idw - Informationsdienst
Wissenschaft

Science Video Project
idw-Abo

idw-News App:

AppStore

Google Play Store

Event


institutionlogo

04/16/2019 - 04/16/2019 | Hannover

TWINCORE Seminar - Prof. Dr. Silke Stertz; Institute of Medical Virology, University of Zurich

MHC class II proteins mediate cross-species entry of bat influenza viruses

Silke Stertz, Assistenz-Professorin der Molekularen Virologie am Insitut für Medizinische Virologie der Universität Zürich spricht über neue Influenza A Viren in Fledermäusen.

Abstract

In 2012 and 2013 two novel influenza A viruses were discovered in South American bat species. Remarkably, the hemagglutinin of these bat influenza viruses was found not to bind the canonical influenza virus receptor, sialic acid, or any other glycan, despite high sequence and structural homology with conventional influenza A virus hemagglutinins. Using transcriptomic profiling of susceptible versus non-susceptible cells, in combination with genome-wide CRISPR/Cas9-based screening, we identified the MHC-II complex HLA-DR as crucial entry factor for bat influenza viruses. CRISPR/Cas9-mediated knockout of HLA-DR rendered susceptible cells completely resistant to bat influenza but not conventional influenza virus infection, whereas ectopic expression of HLA-DR in non-susceptible cells conferred susceptibility to bat influenza virus infection. Expression of MHC-II complexes from three different bat species, nice, pigs or chickens also conferred susceptibility. Notably, infection of mice with bat influenza virus resulted in robust virus replication in the upper respiratory tract, whereas mice deficient for MHC-II were resistant to infection. Collectively, our data identify MHC-II from multiple species as crucial entry determinant for bat influenza virus, suggesting the potential for broad vertebrate tropism.

Information on participating / attending:

Date:

04/16/2019 17:00 - 04/16/2019 18:00

Event venue:

Feodor-Lynen-Str. 7
TWINCORE Seminar room 0.02
30625 Hannover
Niedersachsen
Germany

Target group:

Scientists and scholars, Students

Email address:

Relevance:

local

Subject areas:

Biology, Medicine

Types of events:

Presentation / colloquium / lecture, Seminar / workshop / discussion

Entry:

02/14/2019

Sender/author:

Dr. Jo Schilling

Department:

Presse- und Öffentlichkeitsarbeit

Event is free:

yes

Language of the text:

German

URL of this event: http://idw-online.de/en/event62845

Attachment
attachment icon Veranstaltungsposter

Help

Search / advanced search of the idw archives
Combination of search terms

You can combine search terms with and, or and/or not, e.g. Philo not logy.

Brackets

You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).

Phrases

Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.

Selection criteria

You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).

If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).