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Image for: UDE: Outstanding publication in Science Magazine - How hosts recognize bacteria


A bacterial 23S ribososmal (r) RNA segment activates the Toll-like receptor 13. This 23S rRNA segment is known to also bind antibiotics such as erythromycin (ery). Its central adenosine (A) 2085 in S. aureus and A2058 in E. coli 23S rRNA is mutated or methylated in ery resistant bacteria.
A bacterial 23S ribososmal (r) RNA segment activates the Toll-like receptor 13. This 23S rRNA segment is known to also bind antibiotics such as erythromycin (ery). Its central adenosine (A) 2085 in S. aureus and A2058 in E. coli 23S rRNA is mutated or methylated in ery resistant bacteria.

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