idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
A) Herkömmliches Screeningverfahren mittels kombinatorischer Chemie und Hochdurchsatz-Screening: Eine Substanzbibliothek von Molekülen mit (nahezu) jeder möglichen Kombination wird synthetisiert und am Zielprotein getestet. B) Konzept der fragmentbasierten Leitstruktur: Die drei geometrischen Formen stehen für Fragmente, die an das Zielprotein binden. Diese können chemisch verbunden werden. Trotz kleinerer Substanzbibliotheken, kann so schneller die passende Leitstruktur gefunden werden.
Abb.: FMP
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