idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract:
As potential candidates for designing new drugs against tuberculosis, the genes encoding LeuD, LeuC, LeuB and IlvE, involved in leucine biosynthesis in M. tuberculosis were targeted for structure determination.
All four targeted genes were sucessfully cloned, expressed in soluble form in E. coli expression hosts. The structure of LeuB was determined in apo-form, in complex with substrate (Isopropylmalate) and in complex with Mg-ion. High throughput screening resulted in identification of an inhibitor with IC50 of about 35 micromolar.
Information on participating / attending:
Das Institut für Chemie und Biochemie lädt gemeinsam mit dem Ortsverband der Gesellschaft Deutscher Chemiker zu diesem Kolloquium ein.
Einladender: Prof. Dr. Winfried Hinrichs, Institut für Chemie und Biochemie, Telefon 03834 86-4356
Date:
06/08/2006 17:00 - 06/08/2006
Event venue:
Großer Hörsaal, Institut für Chemie und Biochemie,
Soldmannstraße 16
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
international
Subject areas:
Biology, Chemistry
Types of events:
Entry:
05/31/2006
Sender/author:
Sabine Köditz
Department:
Hochschulkommunikation
Event is free:
no
Language of the text:
English
URL of this event: http://idw-online.de/en/event17329
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