idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
All organelles in a higher organism - the nucleus, mitochondria, chloroplasts, endoplasmic reticulum (ER), and others - perform specific functions and must therefore contain a certain set of proteins. Most of these proteins are synthesized in the cytosol, but specific "zip codes" or "signal sequences" direct them to their different final destinations. During their transport, many of these proteins have to traverse at least one membrane or need to be integrated into a membrane. The mechanisms by which signal sequences are recognized and by which proteins are transported is best understood for the endoplasmic reticulum (ER). Structural and biochemical data show that signal sequences open a protein-conducting channel, allowing polypeptides to move across or integrate into the membrane. Organelles also have characteristic shapes that are generated by specific proteins, and the mechanisms by which they function are being unraveled.
Tom Rapoport: Studium der Mathematik und Naturwissenschaften (1965-1966) und der Chemie und Biochemie (1966-1972) an der Humboldt Universität, Berlin, Promotion (1972) und Habilitation (1977) ebendort. Assistent am Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR in Berlin-Buch (1972-1985), Professor für Zellbiologie und Gruppenleiter am Institut für Molekularbiologie (1985-1992) ebendort, Gruppenleiter am Max-Delbrück-Centrum für Molekulare Medizin, Professor für Zellbiologie an der Harvard Medical School (1995), seit 1997 Howard Hughes Medical Institute Investigator und Professor für Zellbiologie an der Harvard Medical School. Verschiedene Preise und Auszeichnungen, u. a. Johannes-Müller Preis für Experimentelle Medizin, Rudolf-Virchow-Preis. Mitglied u. a. bei EMBO, FASEB, Academia Europaea. Mitglied der Editorial Boards zahlreicher Zeitschriften, z. B. FEBS Letters, EMBO Journal, The Journal of Cell Biology.
Forschungsschwerpunkte: intrazellulärer Proteintransport, Proteintransport durch das Endoplasmatische Reticulum
Seit 2003 ist Tom Rapoport Mitglied der Deutschen Akademie der Naturforscher Leopoldina (Sektion Biochemie und Biophysik).
Kontaktadresse: Prof. Dr. Tom A. Rapoport, HHMI, Harvard Medical School, Dept. of Cell Biology, 240 Longwood Ave., Boston, MA 02115-6091, USA
Information on participating / attending:
Date:
10/23/2007 17:30 - 10/23/2007 18:30
Event venue:
Emil-Abderhalden-Straße 36, Vortragsgebäude der Akademie Leopoldina
06108 Halle (Saale)
Sachsen-Anhalt
Germany
Target group:
Scientists and scholars, Students
Relevance:
transregional, national
Subject areas:
Biology, Chemistry
Types of events:
Entry:
10/16/2007
Sender/author:
Prof.Dr. Jutta Schnitzer-Ungefug
Department:
Presse- und Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event21695
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