idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Stem cells continuously produce cells to form an organism during development or to replace old cells in an adult. The progenitor cells produced by the stem cells undergo a hierarchical process in which their self-renewal capability is lost and a specific lineage identity is adopted. This development is directed by lineage specific transcription factors, which turn off genes important for stem cell functions and initiate the expression of genes important for differentiation. Transcription factors recruit gene regulative complexes that contain cofactors with DNA and histone modifying activity to target genes. By these chromatin modifications the chromatin is reorganised locally and genome-wide to initiate and maintain a cell type specific gene expression pattern. Mutations can change the way transcription factors interact with these epigenetic cofactors and thus they are the cause of an altered chromatin structure. As a consequence gene expression can be deregulated in a way that stem cell functions and differentiation processes become imbalanced. This can give rise to a cancer stem cell population that is able to self-renew like a stem cell but the progenitors produced exhibit a blockage in terminal differentiation.
Thus the identification of transcriptional regulators and the characterisation of mechanisms of transcriptional control is key for the understanding of developmental processes and disease. This symposium brings together scientists who work on different aspects of transcriptional control.
Information on participating / attending:
Die Veranstaltung ist kostenlos, Anmeldung wird erbeten. Veranstaltungssprache ist Englisch.
Date:
03/26/2009 17:00 - 03/27/2009 16:00
Event venue:
Georg-Speyer-Haus
Institute for Biomedical Research
Paul-Ehrlich-Straße 42 - 44
60596 Frankfurt
Hessen
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
regional
Subject areas:
Biology, Medicine
Types of events:
Entry:
01/27/2009
Sender/author:
Christine Kost
Department:
Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
German
URL of this event: http://idw-online.de/en/event26071
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