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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract: In the last years, much research has been focused on development of novel microcapsules for biomedical applications as drug delivery systems. The next generation of carriers is represented by multicompartmentalized micro- and nanocapsules with increased complexity which allows simultaneous delivery of several vectors or biomolecules [1]. A novel approach to investigate release of encapsulated materials from polyelectrolyte multilayer capsules upon mechanical deformation is presented by combining fluorescence microscopy with AFM force spectroscopy [2]. This approach provides very useful information for designing microcapsules suitable for intra-cellular delivery of biomolecules, as well as understanding mechanics of cells. Opto-nanoporation, a method of creating nanometer size pores upon laser illumination, was applied for simultaneous release of large and small molecules from red blood cells (RBCs). By adsorbing gold nanoparticle aggregates on the membrane of RBCs, upon near-IR laser illumination, generated localized heating affects the permeability of the membrane [3]. This is relevant for generating nanometer channels in polymeric and living membranes and to simultaneous drug delivery with potential applications in cancer treatment. Currently, we are creating nano/micro-engineered surfaces to develop sensory surfaces for biomedical applications (e.g. diagnostic) and to study cell dynamics and cell mechanics with potential applications in tissue engineering and designing improved implant surfaces (e.g. pacemakers).
[1]. Delcea, M., Yashchenok, A.M., Videnova, K., Kreft, O., Möhwald, H., and Skirtach, A.G. (2010) Macromolecular Bioscience 10, 465-474.
[2]. Delcea, M., Schmidt, S., Palankar, R., Fernandes, P.A.L., Fery, A., Möhwald, H., and Skirtach, A.G. “Mechanobiology: Correlation Between Mechanical Stability of Microcapsules Studied by AFM and Impact of Cell-Induced Stresses” (2010) Small 6, 2858-2862.
[3]. Delcea, M., Sternberg, N., Georgieva, R., Bäumler, H., Möhwald, H., and Skirtach, A. G. “Nanoplasmonics for dual-molecule release through nanopores in the membrane of red blood cells”(2012) ACS Nano 6, 4169–4180.
Information on participating / attending:
Termin:Dezember 05, 14:15 - 15:15 Uhr
Ort:Institut für Biochemie, Großer Hörsaal
Einladende: Prof. Dr. Sabine Müller
Vorsitzende des Ortsverbandes der GDCh: PD Dr. Heike Kahlert
Weitere Informationen: Institut für Biochemie, Felix-Hausdorff-Straße 4, 17487 Greifswald, Telefon 03834 86-4304, balzer@uni-greifswald.de
Date:
12/05/2012 14:15 - 12/05/2012 15:15
Event venue:
Großer Hörsaal, Institut für Biochemie
Felix-Hausdorff-Straße 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Scientists and scholars, Students
Relevance:
regional
Subject areas:
Biology, Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
11/05/2012
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
no
Language of the text:
German
URL of this event: http://idw-online.de/en/event41641
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