idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abstract
Hepatitis C virus (HCV) infects over 71 million people worldwide and kills more people in the United States annually than HIV. Direct-acting antiviral (DAA) therapy has revolutionized care, but development of a vaccine for HCV remains essential for disease eradication. The enormous genetic diversity of HCV makes this a daunting challenge. Early development of broadly-neutralizing antibodies is associated with spontaneous clearance of HCV infection, but the mechanisms of immune-mediated clearance are poorly defined. We have isolated broadly neutralizing monoclonal antibodies (bNAbs) from individuals who cleared HCV infection, and studied how these antibodies can drive viral evolution, leading to a loss of replicative fitness. We are also studying the structural interactions between these bNAbs and HCV envelope proteins to identify conserved binding epitopes and antibody features critical for neutralizing breadth, with the goal of informing HCV vaccine development.
About Justin Bailey
Dr. Bailey is an Associate Professor of Medicine and an Infectious Diseases physician at the Johns Hopkins University School of Medicine in Baltimore, Maryland. He earned his M.D. and Ph.D. degrees from Johns Hopkins and completed medical residency training at Massachusetts General Hospital in Boston, Massachusetts. His laboratory focuses on virus-host interactions, with a particular focus on broadly neutralizing antibodies against hepatitis C virus (HCV).
Information on participating / attending:
Date:
03/26/2019 17:00 - 03/26/2019 18:00
Event venue:
Feodor-Lynen-Str. 7
TWINCORE Seminar room 0.02
30625 Hannover
Niedersachsen
Germany
Target group:
Scientists and scholars, Students
Email address:
Relevance:
local
Subject areas:
Biology, Medicine
Types of events:
Presentation / colloquium / lecture, Seminar / workshop / discussion
Entry:
02/14/2019
Sender/author:
Dr. Jo Schilling
Department:
Presse- und Öffentlichkeitsarbeit
Event is free:
yes
Language of the text:
German
URL of this event: http://idw-online.de/en/event62844
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