idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
idw - Informationsdienst
Wissenschaft
06/09/2011 - 06/09/2011 | Greifswald
Prof. Dr. Per Berglund (KTH Royal Institute of Technology, School of Biotechnology, Stockholm, Sweden):
ω-Transaminases (EC 2.6.1.18) are attractive biocatalysts for synthesis of chiral amines. These enzymes catalyze transfer of an amino group from a donor substrate to an acceptor carbonyl compound using the cofactor pyridoxal-5´-phoshate (PLP). ω-Transaminases do not require a carboxylic acid group in a-position (in contradiction to a-transaminases) and hence accept a wider spectrum of ketones or amines.
Our homology model-based rational design approach will be discussed in the lecture including some results to convert an S-selective ω-transaminase variant from Arthrobacter citreus to an R-selective variant. This homology modelling/rational design approach has further been applied to optimize ω-transaminase from Chromobacterium violaceum.
Einladender : Prof. Dr. Uwe Bornscheuer
gez. Prof. Dr. J. Heinicke
Vorsitzender des Ortsverbandes der
GDCh
Information on participating / attending:
Date:
06/09/2011 17:00 - 06/09/2011
Event venue:
Großer Hörsaal des Instituts für Biochemie
Felix-Hausdorff-Str. 4
17489 Greifswald
Mecklenburg-Vorpommern
Germany
Target group:
Business and commerce, Scientists and scholars
Email address:
Relevance:
transregional, national
Subject areas:
Chemistry
Types of events:
Presentation / colloquium / lecture
Entry:
05/20/2011
Sender/author:
Sabine Köditz
Department:
Presse- und Informationsstelle
Event is free:
yes
Language of the text:
English
URL of this event: http://idw-online.de/en/event35497
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