idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Die Bindung von Sonig Hedgehog (Shh) an seinen Rezeptor Patched (Ptch) aktiviert Smo. Im bislang bekannten klassischen Signalweg aktiviert Smo daraufhin den Gli-Transkriptionsfaktoren, die das Ablesen von Genen regulieren. Im neu entdeckten Signalweg löst die Aktivierung von Smo den Einstrom von Kalzium aus und führt zur Aktivierung verschiedener Kalzium-abhängiger Enzyme wie die Calmodulin-Kinase (Camkk2), AMP-aktivierte Kinase (Ampk) und Leberkinase B1 (Lkb1). Dieser Signalweg kann auch spezifisch von Wirkstoffen wie Cyclopamin aktiviert werden. Beide Signalwege verändern den Stoffwechsel von Muskel- und braunen Fettzellen und ermöglichen es ihnen, schnell große Mengen Glukose aufzunehmen und zu verwerten.
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