Die Trennung der Chromosomen initiiert eine molekulare Nanomaschine, der sogenannte "Anaphase einleitende Komplex" (kurz "APC/C"). Wird der Spindel-Checkpoint aktiviert, lagert sich an APC/C ein zweiter kleiner Proteinkomplex an - quasi ein molekularer "Agent" (rot) - und unterbindet die Wechselwirkung des Komplexes mit anderen Partnern in der Zelle. Als Folge können die Chromosomen nicht mehr getrennt werden. Im Hintergrund: Zellen während der Zellteilung.
Peters, IMP & Stark, MPIbpc
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