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Image for: MDC Researchers and Clinical Partners Identify Mediator of Blood Pressure Regulation in the Liver


Pressor Reflex Triggered by Water Intake.pdf In humans, a pressor reflex is triggered simply by drinking tap water. After passing through the esophagus and stomach, the water is absorbed by the small intestine and is then swept on towards the liver in portal vein blood. MDC-scientists and their clinical partners have now found a new population of osmoreceptors in the liver, which detect the slightest physiological shifts in blood osmolality, a specific measure of the human water balance. If the osmolality decreases below its set point, the osmoreceptors send an electrical signal. This signal triggers an action potential, which in turn stimulates the hepatic vessels to raise blood pressure.
Pressor Reflex Triggered by Water Intake.pdf In humans, a pressor reflex is triggered simply by drinking tap water. After passing through the esophagus and stomach, the water is absorbed by the small intestine and is then swept on towards the liver in portal vein blood. MDC-scientists and their clinical partners have now found a new population of osmoreceptors in the liver, which detect the slightest physiological shifts in blood osmolality, a specific measure of the human water balance. If the osmolality decreases below its set point, the osmoreceptors send an electrical signal. This signal triggers an action potential, which in turn stimulates the hepatic vessels to raise blood pressure.

(Graphic: Dr. Stefan Lechner/ Copyright: MDC)

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