idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Der Abbau von gespeicherten Fetten in Form von Triacylglycerol wird von spezifischen Enzymen vollzogen: Adipose triglyceride lipase (ATGL) katalysiert den ersten und geschwindigkeitsbestimmenden Schritt und spaltet dabei Triacylglycerol in Diacylglycerol und ein Molekül freier Fettsäure (FA). Die Aktivität von ATGL wird durch das Protein ‚CGI-58‘ verstärkt, und durch das Protein ‚G0S2‘ gehemmt. Das entstandene Diacylglycerol wird von der ‚Hormon sensitiven Lipase‘ (HSL) weiter in Monoacylglycerol und ein Molekül freier Fettsäure gespalten. Im letzten Schritt spaltet dann Monoglyzerid Lipase (MGL) das Monoacylglycerol in glycerol und eine weitere frei Fettsäure.
Foto: Institut für Molekulare Biowissenschaften, Uni Graz
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