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The dashed line marks the region of the neural tube out of which the forebrain develops. There in mouse embryos, a binding site (lipoprotein receptor LRP2) (green) for cholesterol is normally found (left image). This binding site plays a key role in the development of the forebrain. The signaling molecule sonic hedgehog (SHH) (red) arises from the structure marked with the arrow below the neural tube (prechordal plate) and accumulates in the overlying neural tube. Therefore a red signal is also visible in the forebrain structure. In mouse embryos in which the gene encoding LRP2 has been inactivated (right image), SHH is produced in the prechordal plate (arrow), but the signaling molecule does not accumulate in the overlying marked forebrain structure. The LRP2 receptor is lacking (no green signal).
(Photo: Annabel Christ/Copyright MDC)
(378 KB, 813 x 367 pixels)
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