Das Schema rechts oben zeigt den typischen Aufbau eines Adhäsions-GPCR. Diese Proteine haben vielfältige Funktionen in Geweben. Sie sind zum Beispiel für die geordnete Ausrichtung der Flügelhaare von Taufliegen wichtig (oben links Wildtyp-Zustand; im Bild darunter fehlt der Adhäsions-GPCR „Flamingo“). Die drei Bilder unten belegen, dass in Darmkrebszellen der Adhäsions-GPCR CD97 (in grün) an der Zellmembran vorkommt wie F-Actin (in rot), ein Baustein des Zellskeletts, das unter der Membran zu finden ist.
Bild: Tobias Langenhan / Gabriela Aust
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