Die Bindung von Sonig Hedgehog (Shh) an seinen Rezeptor Patched (Ptch) aktiviert Smo. Im bislang bekannten klassischen Signalweg aktiviert Smo daraufhin den Gli-Transkriptionsfaktoren, die das Ablesen von Genen regulieren. Im neu entdeckten Signalweg löst die Aktivierung von Smo den Einstrom von Kalzium aus und führt zur Aktivierung verschiedener Kalzium-abhängiger Enzyme wie die Calmodulin-Kinase (Camkk2), AMP-aktivierte Kinase (Ampk) und Leberkinase B1 (Lkb1). Dieser Signalweg kann auch spezifisch von Wirkstoffen wie Cyclopamin aktiviert werden. Beide Signalwege verändern den Stoffwechsel von Muskel- und braunen Fettzellen und ermöglichen es ihnen, schnell große Mengen Glukose aufzunehmen und zu verwerten.
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