Mäuse, denen der Blutgerinnungsfaktor XII fehlt (FXII -/-) oder die mit einer Substanz behandelt wurden, die den Faktor hemmt (PCK), haben deutlich kleinere Schlaganfälle als die entsprechenden Kontrolltiere (wt und Kontr). Die Schlaganfälle erscheinen in Gewebeschnitten (A) und in der Kernspintomographie (B) weiß. Nach der Zugabe von humanem Faktor XII (+hFXII) nimmt die Infarktgröße bei den Mäusen, die zuwenig von dem Faktor haben, wieder zu.
Source: Grafik: Thomas Renné
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