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Image for: Bayreuth study on the activation of the enzyme sirtuin 6: Toward the development of drugs for aging-related diseases


The Sirt6 activators UBCS039 (cyan, front left) and MDL-801 (multi-coloured, front right) are anchored in the same binding pocket of Sirt6. The longer MDL-801 molecule also contacts adjacent surface areas and interacts more strongly with Sirt6.
The Sirt6 activators UBCS039 (cyan, front left) and MDL-801 (multi-coloured, front right) are anchored in the same binding pocket of Sirt6. The longer MDL-801 molecule also contacts adjacent surface areas and interacts more strongly with Sirt6.

Illustration: Clemens Steegborn

(1103 KB, 1956 x 1001 pixels)

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