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Stress activates p53. This leads to the activation of RFX7, which, like p53, is a transcription factor and tumor suppressor. RFX7 inhibits the kinases AKT and mTORC1, important regulators of cell growth, which may enable RFX7 to suppress cancer.
(Source: FLI / Kerstin Wagner; created with BioRender.com)
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