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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Retrotranspositionszyklus des humanen LINE-1-Elementes. LINE-1-RNA wird im Zellkern von der DNA abgeschrieben (transkribiert) und anschließend im Zytoplasma vom Ribosom in zwei Proteine (L1ORF1p und L1ORF2p) übersetzt (translatiert). Beide Proteine binden dann an die LINE-1-RNA und bilden einen RNA-Protein-Komplex. Zurück im Zellkern schneidet das L1ORF2p-Protein dann die DNA auf und beginnt mit der Rückübersetzung (Reverser Transkription) der LINE-1-RNA in DNA, die am Ort der Schnittstelle in das Genom integriert wird. Wahrscheinlich unterstützt das L1ORF1p Protein diesen Prozess.
Elena Khazina und Oliver Weichenrieder / Max-Planck-Institut für Entwicklungsbiologie
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