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05/26/2009 13:55

Salmonella and self-sacrifice

Presse- und Informationsdienst Presse- und Informationsdienst
Schweizerischer Nationalfonds SNF

    How diarrhoea pathogens multiply in our intestines

    Our large intestines are heavily populated by bacteria and as such really do not have space for newcomers. Despite this, Salmonella are able to multiply there. In a project funded by the Swiss National Science Foundation, a group led by Wolf-Dietrich Hardt from ETH Zurich is uncovering the remarkable strategies used by the feared diarrhoea pathogens. A small number of the Salmonella sacrifice themselves by attacking the intestinal cells. Although this kills them, they succeed in causing inflammation. The inflamed intestine excretes mucus, which ultimately accelerates the growth of the remaining salmonella in the intestine. Thus the bacteria benefit from the death of their sister cells.

    Prof. Wolf-Dietrich Hardt
    Institute of Microbiology
    Department of Biology, ETH Zurich
    ETH Hönggerberg, HCI G 417
    Wolfgang-Pauli Str. 10
    CH-8093 Zurich
    E-mail: hardt@micro.biol.ethz.ch
    Tel.: +41 44 632 51 43
    Fax: +41 44 632 11 29
    http://www.micro.biol.ethz.ch


    More information:

    http://www.snf.ch > Media > Picture of the month
    http://www.micro.biol.ethz.ch


    Images

    Salmonella (red) have to prevail against the intestinal flora (small green dashes). They will succeed if some of them manage to attack the intestinal wall (blue). Although the attacking bacteria are killed, they cause inflammation which the remaining Salmonella can benefit from to proliferate.
    Salmonella (red) have to prevail against the intestinal flora (small green dashes). They will succee ...
    Source: © Bärbel Stecher and Wolf-Dietrich Hardt, Institute of Microbiologye ETH Zurich/SNSF


    Criteria of this press release:
    Medicine, Nutrition / healthcare / nursing
    transregional, national
    Miscellaneous scientific news/publications, Research projects
    English


     

    Salmonella (red) have to prevail against the intestinal flora (small green dashes). They will succeed if some of them manage to attack the intestinal wall (blue). Although the attacking bacteria are killed, they cause inflammation which the remaining Salmonella can benefit from to proliferate.


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