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Nachrichten, Termine, Experten
A specific group of white blood cells, termed "regulatory T cells", keeps the immune system in balance and suppresses its activity to protect the body against autoimmune diseases. Scientists at the DZNE and the University of Bonn have now discovered a new mechanism by which regulatory T cells inhibit inflammation specifically in adipose tissue. This mechanism plays an important role in protecting against type 2 diabetes, as an overactive immune system in adipose tissue can promote insulin resistance and thus contribute to this metabolic disease. The study is now published in the journal “Immunity”.
Complete press release: https://www.dzne.de/en/news/public-relations/press-releases/press/detail/how-the...
Schmidleithner et al. (2019): “Enzymatic activity of HPGD in Treg cells suppresses Tconv cells to maintain adipose tissue homeostasis and prevent metabolic dysfunction”, Immunity
DOI: 10.1016/j.immuni.2019.03.014
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