Phagocytes versus killer cells - A closer look into the tumour tissue

idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
idw-Abo
Medienpartner:
Wissenschaftsjahr


Share on: 
10/18/2019 20:00

Phagocytes versus killer cells - A closer look into the tumour tissue

Dr. Alexandra Nießen Ressort Presse - Stabsstelle des Rektorats
Universität Duisburg-Essen

    They are first class at fighting infections. However, neutrophils, specialized phagocytic white blood cells of the immune system, can also promote the growth of cancer. A research team led by Professor Sven Brandau from the Ear, Nose and Throat Clinic of the University Hospital Essen (UK Essen) has now been able to show this for the first time in human tumour tissue. The results are published in the current issue of the renowned journal Science Immunology.

    „It was already known that cancer patients that have many of these immune cells migrated into their tumour tissue have reduced survival rates”, says Sven Brandau, head of the Department of Experimental und Translational Research. „Therefore, experts suspected that those phagocytic cells, the so-called neutrophils, could inhibit the fight of the killer immune cells against cancer.“

    Using advanced microscopy technologies and analyses, Brandau and his collaborators have now uncovered the interaction between the neutrophils and killer cells in tumour tissue. „We were able to show that the neutrophils actually touch the killer cells and prevent the killing of the cancer cells.“

    In future investigations, the researchers at the UK Essen would like to block the entry of the phagocytes into the tumour tissue in order to develop novel immunotherapies against cancer.

    Cooperation partners in the study were teams from dermatology and experimental immunology.

    Editor: Milena Hänisch, Phone +49 201/723-6274, milena.haenisch@uk-essen.de
    Translation: Alexandra Niessen, Phone +49 203/37 9-1487, alexandra.niessen@uni-due.de


    Contact for scientific information:

    Prof. Dr. Sven Brandau, Phone: +49 201/723-3193, Sven.brandau@uk-essen.de


    Original publication:

    https://immunology.sciencemag.org/


    Criteria of this press release:
    Journalists, Scientists and scholars, all interested persons
    Biology, Chemistry, Medicine, Social studies
    transregional, national
    Research results, Transfer of Science or Research
    English


    Help

    Search / advanced search of the idw archives
    Combination of search terms

    You can combine search terms with and, or and/or not, e.g. Philo not logy.

    Brackets

    You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).

    Phrases

    Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.

    Selection criteria

    You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).

    If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).

    Cookies optimize the use of our services. By surfing on idw-online.de you agree to the use of cookies. Data Confidentiality Statement
    Okay