idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Science Video Project

idw-News App:


Google Play Store

Share on: 
01/10/2022 12:36

Marijn Kuijpers receives ERC Starting Grant

Silke Oßwald Presse- und Öffentlichkeitsarbeit
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

    The prestigious Starting Grant from the European Research Council (ERC) was awarded to Dr. Marijn Kuijpers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP). Kuijpers will use the 1.5-million-euro grant to study a large intracellular organelle called the Endoplasmic Reticulum (ER) in nerve cells.

    The inside of a cell is organized into separate compartments, or organelles, that fulfil specific functions. The nucleus for instance, houses our genetic material while mitochondria create the energy needed to fuel cellular processes. The endoplasmic reticulum (or ER) is the largest organelle inside our cells and serves many roles, from the production and transport of proteins and lipids, to the storage of calcium. While malfunctioning of the ER is linked to the development of neurodegenerative disorders we know very little about how this huge organelle supports the unique function of the cells in our nervous system.
    Nerve cells are responsible for our ability to remember and to coordinate all of the necessary functions of life. Nerve cells have some very unique features, for instance, they are very large, as their main task is to transmit impulses over extremely long distances. This important task of signal transmission is also reflected in the nerve cell’s asymmetry, with processes called dendrites that receive impulses from other nerve cells and one thin, very long process called the axon that transmits the signal to other cells. To grow and maintain these large, functionally diverse structures, nerve cells depend on proper sorting and transport of proteins, lipids and a correct distribution of other cellular elements, processes in which the ER could play a vital role. In addition, the transmission of nerve impulses heavily relies on changes in calcium concentrations, pointing to an additional role the ER could have in these cells.
    The team will use innovative imaging techniques that allow the visualization of ER resident proteins, ER dynamics and ER processes such as calcium storage inside the nerve cell. The awarded project synERgy will help scientists to establish the role of the ER in nerve cells to ultimately understand how defects in ER function contribute to neurodegeneration.

    About the ERC Grants: The funding program of the European Research Council (ERC) is one of the most prestigious in Europe. Starting Grants support excellent researchers beginning with their own independent research team or programme and are endowed with up to 1.5 million euros over five years.

    The ER (in blue) in nerve cells, or neurons, is enormous and is also called a “Neuron within a Neuron”. It extends all the way into the long axon. The awarded project will investigate how the different functions of ER play a role in nerve signal transmission and neurodegeneration.

    Contact for scientific information:

    Dr. Marijn Kuijpers
    Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
    Department Volker Haucke

    13125 Berlin, Campus Berlin-Buch


    Neuronal ER
    Neuronal ER

    Marijn Kuijpers

    Criteria of this press release:
    Journalists, Scientists and scholars, all interested persons
    Biology, Chemistry, Medicine
    transregional, national
    Research projects


    Neuronal ER

    For download



    Search / advanced search of the idw archives
    Combination of search terms

    You can combine search terms with and, or and/or not, e.g. Philo not logy.


    You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).


    Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.

    Selection criteria

    You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).

    If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).