idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
A new study has revealed important insights into how SARS-CoV-2 and its variants escape the immune system. The findings pave the way for new therapeutic approaches against COVID-19. The research of the international team of scientists from the USA, Brazil and Germany focused on the interactions between the virus and the human innate immune system. The study was led by a team from the Ragon Institute of Mass General, MIT and Harvard, Cambridge, USA. The results were published in the renowned journal "Cell" on May 9, 2024.
The results of the study show that cells infected with SARS-CoV-2 downregulate important immune signals known as NKG2D ligands. These ligands play a crucial role in activating the immune system, particularly natural killer (NK) cells, which are cells of the innate immune system that are central to fighting viral infections.
In addition, the researchers identified the mechanism by which the virus achieves the downregulation of these immune signals. It was found that a viral protein called ORF6 is significantly involved in this process. 76C, an antibody that is already being tested in preclinical studies in cancer research, prevents this downregulation and makes the infected cells more vulnerable to natural killer cells. This discovery could open up new approaches for the development of therapies against COVID-19.
The study also showed that NK cells play an important role in fighting SARS-CoV-2-infected cells. Despite the virus' efforts to suppress the immune system, NK cells are able to recognize and destroy infected cells. This suggests that activating the innate immune system could be a promising strategy to treat COVID-19.
"Our findings provide important insights into the immune defense against SARS-CoV-2 and how we can potentially strengthen it with new therapies," says Dr. Dr. Angelique Hölzemer, head of the research group Infection & Immune Regulation at the Leibniz Institute of Virology and Clinician Scientist in the Division of Infectious diseases at the I. Department of Medicine at the University Medical Center Hamburg-Eppendorf (UKE). "By better understanding how the virus tries to escape the immune system, we can develop additional approaches to treat COVID-19."
Dr. Dr. Angelique Hölzemer
Phone: 040/48051-224
angelique.hoelzemer@ leibniz-liv.de
Hartmann JA, Cardoso MR, Ramiro Talarico MC, Kenney DJ, Leone MR, Reese DC, Turcinovic J, O’Connell AK, Gertje HP, Marino C, Ojeda PE, De Paula EV, Orsi FA, Velloso LA, Cafiero TR, Connor JH, Ploss A, Hoelzemer A, Carrington M, Barczak AK, Crossland NA, Douam F, Boucau J, Garcia-Beltran WF (2024) Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses.
Doi: https://doi.org/10.1016/j.cell.2024.03.026
Criteria of this press release:
Business and commerce, Journalists, Scientists and scholars, Students, all interested persons
Biology, Medicine
transregional, national
Research results, Scientific Publications
English
You can combine search terms with and, or and/or not, e.g. Philo not logy.
You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).
Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.
You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).
If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).
