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Tumor cells can grow without control by weakening specific cells of the immune system, the T-cells, which normally detect and destroy tumor cells. The findings of Dr. Gerald Willimsky and Prof. Thomas Blankenstein (Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch and Charité) were generated in transgenic mice over a period of seven years and have now been published in the scientific journal Nature* (doi:10.1038/nature03954). Until now, the notion was that tumor cells escape recognition and subsequent destruction by T-cells by hiding.
Furthermore, Dr. Willimsky and Prof. Blankenstein could show that the immune system recognizes tumors derived from single cells and strongly reacts, for example by the increase in T-cells. However, these T-cells do not function. The findings of the two immunologists refer to sporadic tumors which develop without influence from the outside. T-cells on the other hand can control cancers caused by viral infection (e.g., B cell lymphomas triggered by Epstein Barr viruses). Even though tumor cells weaken the immune system, the two researchers are convinced that there is still hope for an immune therapy because tumor cells do not lose their structures which are targets for immune cells, making them still vulnerable for detection and destruction.
*Sporadic immunogenic tumors avoid destruction by inducing T-cell tolerance
Gerald Willimsky1, Thomas Blankenstein1,2
1Institute of Immunology, Charité Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.
2Max-Delbrück-Center for Molecular Medicine, Robert-Roessle-Straße 10, 13125 Berlin, Germany.
Press and Public Affairs
Max Delbrück Center for Molecular Medicine(MDC) Berlin-Buch
Barbara Bachtler
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49/30/9406-38 96
Fax.: +49/30/9406-38 33
e-mail: bachtler@mdc-berlin.de
http://www.mdc-berlin.de
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Biology, Information technology, Medicine, Nutrition / healthcare / nursing
transregional, national
Research results, Scientific Publications
English
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