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03/28/2022 11:00

African killifish: Fewer antibody diversity in old age

Dr. Maren Berghoff Communications
Max-Planck-Institut für Biologie des Alterns

    As we age, our immune system works less well. We become more susceptible to infections and vaccinations no longer work as effectively. A research team led by Dario Riccardo Valenzano investigated whether short-lived killifish undergo aging of the immune system. Indeed, they found that already at four months of age, killifish have less diverse circulating antibodies compared to younger fish, which may contribute to a generalized decrease in the immune function.

    The immune system must constantly respond to new attacks from pathogens and remember them in order to be protected during the next infection. For this purpose, B cells build an information repository and produce a variety of antibodies that can directly recognize the pathogens.

    "We wanted to know about the antibody repertoire in old age," explains Dario Riccardo Valenzano, who led the study. "It is difficult to study a human being's immune system over his or her entire life, because humans live a very long time. Moreover, in humans you can only study the antibodies in peripheral blood, as it is problematic to get samples from other tissues. For this reason, we used the killifish. It is very short-lived and we can get probes from different tissues."

    Killifishes are the shortest-lived vertebrates that can be kept in the laboratory. They live for only three to four months, age in a time-lapse and have become the focus of ageing research in recent years due to these characteristics.

    Less antibody diversity

    The researchers were able to characterize with high accuracy all the antibodies that killifish produce. They found that older killifish have different types of antibodies in their blood than younger fish. They also had a lower diversity of antibodies throughout their bodies.

    "If we have fewer different antibodies as we age, this could lead to a reduced ability to respond to infections. We now want to further investigate why the B cells lose their ability to produce diverse antibodies and whether they can possibly be rejuvenated in the killifish and thus regain this ability," says Valenzano.

    The research for this study was conducted at the Max Planck Institute for Biology of Ageing and was funded by the CECAD Cluster of Excellence for Aging Research and the Collaborative Research Center 1310 at the University of Cologne. Dario Riccardo Valenzano is now group leader of the research group "Evolutionary Biology / Microbiome-Host Interactions in Aging" at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) and Professor at Friedrich Schiller University in Jena.


    Contact for scientific information:

    Dario Riccardo Valenzano, PhD
    Max Planck Institute for Biology of Ageing, Cologne
    Now: Leibniz Institute on Aging – Fritz Lipmann Institute (FLI), Jena
    Phone: +49 (0)3641 65-6280
    Email: Dario.Valenzano@leibniz-fli.de


    Original publication:

    William J Bradshaw, Michael Poeschla, Aleksandra Placzek, Samuel Kean, Dario Riccardo Valenzano
    Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish
    eLife, February 7th, 2022
    https://elifesciences.org/articles/65117


    More information:

    https://www.age.mpg.de/communications/press-material/press-releases/detail/neutr...
    https://www.age.mpg.de/communications/press-material/press-releases/detail/gut-b...
    https://www.age.mpg.de/communications/press-material/press-releases/detail/killi...


    Images

    The African killifish (Notobranchius furzeri) can be used to study the ageing of the immune system.
    The African killifish (Notobranchius furzeri) can be used to study the ageing of the immune system.

    Max Planck Institute for Biology of Ageing

    The African killifish (Notobranchius furzeri) is the shortest living vertebrate that can be kept in the laboratory.
    The African killifish (Notobranchius furzeri) is the shortest living vertebrate that can be kept in ...
    Patrick Fouad
    Fouad/ Max Planck Institute for Biology of Ageing


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    Criteria of this press release:
    Journalists
    Biology, Medicine
    transregional, national
    Research results
    English


     

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