idw - Informationsdienst
Wissenschaft
Rheumatoid arthritis (RA) is the most common inflammatory disease of the joints. Nowadays, there are many therapies that can significantly reduce the symptoms However, bone loss and osteoporosis are still a problem. Building on previous studies, researchers at the Leibniz Research Centre for Working Environment and Human Factors in Dortmund (IfADo) have taken a closer look at the role of the neurotransmitter dopamine in the bone metabolism of RA patients. They conclude that dopamine can be used for new therapeutic approaches to control bone loss in rheumatoid arthritis.
In a current project, Prof. Dr. Silvia Capellino's group has investigated the importance of the biochemical messenger dopamine for the bone formation process in rheumatoid arthritis. Dopamine is a neurotransmitter of the central nervous system that controls movement, emotions, and cognition. Dopamine receptors, the receiving unit for signals through the neurotransmitter dopamine, were found in bone tissue.
The presence of dopamine receptors in RA patients suggests that dopamine also plays a role in the physiology of human bone metabolism. Therefore, the researchers hypothesised that the signalling pathway activated by dopamine in inflamed joints also influences bone metabolism in rheumatoid arthritis. From this, they deduced that deciphering these dopamine-regulated signalling pathways in bone metabolism may pave the way for new therapeutic approaches to control bone loss.
Background: Rheumatoid arthritis
Rheumatoid arthritis is an autoimmune disease characterised by chronic joint inflammation and subsequent joint destruction that can lead to complete loss of function. Furthermore, rheumatoid arthritis is not only a disease of the joints but can also affect many other organs and cause systemic osteoporosis, for example.
Current therapies target osteoclasts (bone cells responsible for reducing bone substance) to reduce bone loss. However, more treatment options would be needed to promote bone protection by directly acting on osteoblasts (bone cells responsible for building bone substance).
Prof. Dr. Silvia Capellino
Head of Group Neuroimmunology
Phone: +49 231 1084-420
Email: capellino@ifado.de
Schwendich, E.; Salinas Tejedor, L.; Schmitz, G.; Rickert, M.; Steinmeyer, J.; Rehart, S.; Tsiami, S.; Braun, J.; Baraliakos, X.; Reinders, J.; Neumann, E.; Müller-Ladner, U.; Capellino, S. Modulation of Dopamine Receptors on Osteoblasts as a Possible Therapeutic Strategy for Inducing Bone Formation in Arthritis. Cells 2022, 11, 1609. https://doi.org/10.3390/cells11101609
Criteria of this press release:
Journalists
Biology, Medicine, Nutrition / healthcare / nursing
transregional, national
Research results
English
You can combine search terms with and, or and/or not, e.g. Philo not logy.
You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).
Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.
You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).
If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).