idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
idw - Informationsdienst
Wissenschaft
Inhalable vaccine and vaccine with two antigens will be tested on healthy people
The Centre for Clinical Studies (ZKS) of the Hannover Medical School (MHH) is looking for healthy subjects for two corona vaccine studies. Both studies are in phase I. The tolerability and efficacy of the vaccines will be tested in healthy people.
The first study is about an inhalable Corona vaccine based on a genetically silenced smallpox virus. In technical jargon, it is called "modified vaccinia virus Ankara", or MVA for short. The idea for this vaccine came from MHH immunologist Professor Dr Reinhold Förster, and researchers from MHH and Fraunhofer ITEM have jointly developed the vaccine. In the clinical trial, they want to test the safety and tolerability of this new vaccine as a booster against Covid-19. Healthy women and men between 18 and 60 years of age who have been fully vaccinated against the SARS-CoV-2 virus can participate, provided that the most recent Corona vaccination was at least two to three months ago. A previous Corona infection should also have occurred at least two to three months ago. In addition, the test persons must have been non-smokers for at least one year and be willing to undergo bronchoscopy.
In the second study, the ZKS is testing a Corona vaccine developed by Speransa Therapeutics. The special feature is that this vector vaccine contains two antigens at the same time and thus induces an immune response against the spike protein as well as against the nucleocapsid of the corona virus. The researchers hope that this new approach will lead to a broader immune response compared to previous vaccines that contain only one antigen. Ideally, this vaccine could also be more protective against future mutations of the virus. For this study, the ZKS team is looking for healthy 65- to 85-year-old people who have previously only been vaccinated with an mRNA vaccine and have no previous cardiac disease. They should also have had their most recent Corona vaccination at least two to three months ago and a previous Corona infection at least two months ago.
If you are interested, please contact the MHH study team at the ZKS by phone (0511) 5350-8333 or by e-mail to crc.studienteilnahme@mh-hannover.de .
For further information, please contact Professor Dr. Christoph Schindler, telephone (0511) 5350-8300, schindler.christoph@mh-hannover.de.
A test person inhaling a vaccine
Felix Schmitt, Hannov
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