idw – Informationsdienst Wissenschaft
Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
idw - Informationsdienst
Wissenschaft
Researchers from the Central Institute of Mental Health, Charité – Universitätsmedizin Berlin and the Technical University of Dresden have published study results in the American Journal of Psychiatry that provide a better understanding of the relationship between hormones and alcohol consumption. A gender-separated, multi-center longitudinal study conducted on 74 women with alcohol use disorder who have a natural menstrual cycle and 278 men with alcohol use disorder shows significant correlations between menstrual cycle, the ratio of progesterone to estradiol and problematic drinking behavior.
The study shows that during the late luteal phase of the menstrual cycle, the probability of days with binge drinking in women was 13 % and lower than in the menstrual (17 %), follicular (19 %) and ovulatory phases (20 %). At the same time, the mean value of the progesterone-to-estradiol ratio was higher in the late luteal phase compared to other cycle phases. In men, a higher progesterone-to-estradiol ratio was directly associated with a lower likelihood of binge drinking and any alcohol consumption.
These results suggest that a higher progesterone-to-estradiol ratio may protect women and men with alcohol use disorder from problematic alcohol consumption. This makes the hormone ratio a promising target for future treatment of alcohol use disorder. This could pave the way for personalized, menstrual cycle-dependent treatments, especially for women with alcohol use disorder.
Professor Dr Bernd Lenz and Sabine Hoffmann from the Department of Addictive Behavior and Addiction Medicine at the Central Institute of Mental Health in Mannheim emphasize the importance of this finding: "Our research opens up new perspectives for the treatment of alcohol use disorder. The findings can contribute to the development of gender-specific therapeutic approaches that take into account the biological differences between women and men."
Methods
In the multi-center longitudinal study, the researchers analyzed individual data on real-life alcohol consumption, which was collected via smartphone over a 12-month period, the menstrual cycle and the ratio of progesterone to estradiol in the blood (a total of 667 blood samples from four study visits) in 74 women and 278 men with alcohol use disorder.
About the TRR 265 research consortium
The main risk factors for mortality and morbidity worldwide are alcohol and tobacco consumption. While knowledge about individual factors that promote the initiation and maintenance of substance use is increasing, there is still a lack of knowledge about modulating factors and mechanisms that contribute to loss and regain of control over substance use. A better understanding of these factors and mechanisms will be crucial to improve the treatment of substance use disorders. The goal of the TRR 265 research consortium is to identify the trajectories of loss and regain of control over drug use, investigate the underlying neurobiological and behavioral mechanisms, and develop mechanism-based therapies. More at trr265.org
Hoffmann S et al., Associations of Menstrual Cycle and Progesterone-to-Estradiol Ratio With Alcohol Consumption in Alcohol Use Disorder: A Sex-Separated Multicenter Longitudinal Study. Am J Psychiatry, doi: 10.1176/appi.ajp.20230027
https://doi.org/10.1176/appi.ajp.20230027
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