Resistance to antibiotics is a severe problem in contemporary medicine. Many antibiotics inhibit protein biosynthesis by hampering the ribosome function. Structures of bacterial ribosomes in complex with these antibiotics illuminated common pathways of antibiotics inhibitory action, but not the species-specific diversity in infectious-diseases susceptibility.
Recent structural studies on ribosome from a multi-resistant pathogenic bacterium and careful comparisons to ribosomes from non-pathogenic bacteria revealed novel structural motifs, essential to protein biosynthesis but not located in the primary ribosomal active sites, hence no mechanism for modification leading to resistance of these sites is currently known. These led to the design of antibiotics with desired properties that can be optimized in terms of their chemical properties, toxicity and penetration, alongside species-specificity, thus preserving the microbiome, as well as in terms of bio degradability, thus reducing the ecological hazards caused by the spread of the current antibiotics’ metabolites.
Information on participating / attending:
Die Anzahl der Plätze ist begrenzt. Um eine Anmeldung wird gebeten.
06/12/2019 18:00 - 06/12/2019 20:00
Hörsaal im Kaiserin-Friedrich- Haus
all interested persons
Types of events:
Presentation / colloquium / lecture
Presse- und Öffentlichkeitsarbeit
Event is free:
Language of the text:
URL of this event: http://idw-online.de/en/event59528
You can combine search terms with and, or and/or not, e.g. Philo not logy.
You can use brackets to separate combinations from each other, e.g. (Philo not logy) or (Psycho and logy).
Coherent groups of words will be located as complete phrases if you put them into quotation marks, e.g. “Federal Republic of Germany”.
You can also use the advanced search without entering search terms. It will then follow the criteria you have selected (e.g. country or subject area).
If you have not selected any criteria in a given category, the entire category will be searched (e.g. all subject areas or all countries).