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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Modell für die Regulation von MHC-II-Genen an PML-Kernkörperchen (PML body), die möglicherweise bei der Immunabwehr eine Rolle spielen. (A) In menschlichen Zellen ist der MHC-II-Genlokus (rote Signale) an einem der PML-Kernkörperchen (grüne Signale) positioniert; Abbildung (B) gibt einen Ausschnitt dieser Positionierung wieder. Abbildung (C) zeigt im Modell wie CIITA, der Hauptregulator für die Transkription von MHC-II-mRNAs durch eine feste Bindung an PML-Kernkörperchen stabilisiert wird. (rote Boxen: MHC-II-Gene; grüne Pfeile: Transkription der MHC-II-mRNAs)
Grafik: K. Wagner / FLI; Foto: www.panthermedia.de
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