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Section through nerve fibres within the sciatic nerve as seen under the electron microscope: the axons (nerve cell projections, pink) are only poorly surrounded by a myelin sheath (generated by Schwann cells, coloured blue) following inactivation of the gene encoding BACE1, which controls the myelination process (right panel). The nerve fibres in a control animal (left panel, BACE1 gene is intact) are in contrast surrounded by thick myelin sheaths (dark rings).
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