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Image for: Oxidative stress slows down the brain, but the brake can be released again


Oxidative stress in the aging brain inhibits the activity of deubiquitylases. These enzymes are essential for regulating protein degradation. As a result, ubiquitin tags on proteins are no longer efficiently removed. Notably, this effect is reversible.
Oxidative stress in the aging brain inhibits the activity of deubiquitylases. These enzymes are essential for regulating protein degradation. As a result, ubiquitin tags on proteins are no longer efficiently removed. Notably, this effect is reversible.

Copyright: (Picture: FLI / Kerstin Wagner; AI-generated with Google Gemini)

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