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CT scan of the tibia. Healthy bone (left) is characterized by a lattice of trabecular bone and a clear marrow cavity. The bones of mice, in which the chloride/hydrogen ion exchanger CIC-7 has been converted into a pure chloride conductor (middle) show an irregular cluster of bone tissue, a mild form of osteopetrosis. If the protein CIC-7 is totally lacking (right) the function of the bone degrading cells is completely disrupted, leading to a severe form of osteopetrosis, also known as marble bone disease.
(Photo: Dr. Stefanie Weinert/ Copyright: FMP/MDC)
(222 KB, 1452 x 633 pixels)
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